Table 3. RGYW/WRCY motifs and targeted mutation frequencies in CDR and FR regions.

	Control	Aviremic	Viremic	p value
Number of RGYW/WRCY motifs per VH segment	17.8 (11–23)	18.3 (13–23)	17.8 (13–24)	0.11
% of CDR nucleotides mutated	13.5 (7.4–15.2)	12.4 (10.2–14.1)	9.8 (4.9–14.4)	0.04a
% of CDR mutations present in RGYW/WRCY motifs	58.8 (48.5–62.5)	61.1 (56.8–71.0)	59.4 (53.5–69.2)	0.32
% of FR nucleotides mutated	5.2 (4.0–6.5)	4.8 (4.2–5.7)	4.1 (2.4–7.8)	0.18
% of FR mutations present in RGYW/WRCY motifs	29.3 (19.6–33.5)	30.1 (27.3–33.0)	28.7 (24.4–35.2)	0.55
% of all nucleotides mutated	7.2 (6.0–8.4)	6.5 (5.6–7.6)	5.3 (3.1–9.3)	0.14
% of all mutations present in RGYW/WRCY motifs	41.2 (31.9–46.3)	43.3 (39.9–48.6)	41.4 (37.1–45.6)	0.29

Group medians are listed with the range of individual means in each group in parentheses. Overall p values are listed on the table.

^a Secondary analyses: control vs. viremic p<0.05; all other comparisons p>0.05.