Table 4. Nucleotide mutation patterns and proportions in IgG VH3 mRNA sequences.
| Control | Aviremic | Viremic | p value | |
| CDR | ||||
| % C nucleotides mutated | 13.03 (9.1–16.8) | 13.8 (10.2–16.0) | 10.29 (6.9–19.0) | 0.13 |
| % G nucleotides mutated | 15.06 (17.5–19.2) | 14.0 (12.9–17.8) | 11.04 (6.2–16.9) | 0.03a |
| % A nucleotides mutated | 13.12 (6.8–16.2) | 12.1 (8.1–13.8) | 9.69 (3.9–14.4) | 0.05b |
| % T nucleotides mutated | 9.96 (6.9–11.5) | 9.1 (8.0–10.3) | 7.64 (2.5–13.4) | 0.08 |
| FR | ||||
| % C nucleotides mutated | 5.32 (3.9–7.4) | 5.4 (4.4–6.4) | 3.97 (2.2–7.5) | 0.21 |
| % G nucleotides mutated | 5.38 (4.2–7.5) | 5.1 (4.7–6.1) | 4.20 (2.6–8.7) | 0.09 |
| % A nucleotides mutated | 5.77 (4.8–6.8) | 5.4 (4.6–6.6) | 4.83 (3.2–9.1) | 0.23 |
| % T nucleotides mutated | 3.43 (2.2–4.0) | 3.4 (2.6–4.1) | 2.72 (0.9–5.2) | 0.37 |
| CDR | ||||
| % of mutations that were C nts | 19.06 (17.5–26.8) | 20.4 (18.1–22.5) | 20.08 (17.0–29.1) | 0.73 |
| % of mutations that were G nts | 30.85 (26.9–50.2) | 33.1 (29.3–38.1) | 31.33 (27.0–38.3) | 0.58 |
| % of mutations that were A nts | 30.36 (26.9–35.0) | 28.5 (24.7–35.3) | 29.28 (24.6–36.3) | 0.61 |
| % of mutations that were T nts | 19.33 (11.8–21.7) | 17.4 (14.3–20.3) | 17.06 (12.0–22.5) | 0.28 |
| FR | ||||
| % of mutations that were C nts | 27.87 (23.8–33.6) | 27.2 (25.8–30.7) | 26.95 (22.7–33.0) | 0.50 |
| % of mutations that were G nts | 35.70 (29.5–48.9) | 35.0 (33.2–36.4) | 34.14 (31.5–39.7) | 0.32 |
| % of mutations that were A nts | 24.74 (21.7–35.0) | 23.0 (20.9–24.6) | 24.66 (21.2–29.4) | 0.10 |
| % of mutations that were T nts | 13.32 (10.5–20.0) | 14.4 (11.9–17.0) | 14.36 (11.0–17.0) | 0.59 |
“% C nucleotides mutated” indicates the proportion of nucleotides in either the CDR1/2 or FR1/2/3 regions that were mutated relative to the total number of C nucleotides present in the unmutated reference sequence, expressed as a percent. “% of mutations that were C nts” indicates the proportion of mutations in either the CDR1/2 or FR1/2/3 regions that were C nucleotides in the unmutated reference sequence relative to the total number of mutations in the region expressed as a percent. The group medians are listed (individual patient mean ranges in parentheses). Overall p values are listed on the table.
a Secondary analyses: all comparisons p>0.05.
b Secondary analyses: control vs. viremic p<0.05; all other comparisons p>0.05.