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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Curr Opin Immunol. 2013 Aug 23;25(6):10.1016/j.coi.2013.07.012. doi: 10.1016/j.coi.2013.07.012

Figure 4.

Figure 4

Models of Be presentation to CD4+ T cells in the context of MHCII molecules. A, A schematic model for the direct binding of Be to the MHCII/peptide complex is shown. B, A direct model of interaction is depicted where the metal binds to the antigenic peptide alone. C, The potential ability of Be to alter the MHCII peptide repertoire that is capable of bindings due to the presence of Be in the peptide-biding groove is shown. D, The preferred model depicting the ability of Be to alter the conformation of self-peptides that are subsequently recognized as neoantigens by the TCR is shown. It remains unknown whether the Be-specific TCR directly contacts Be or recognizes an altered self-peptide with no direct contacts between the metal and the TCR (as shown in Figure 4D).