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. 2014 Jan 7;9(1):e84478. doi: 10.1371/journal.pone.0084478

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© 2014 Ichimura et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Raman images of Neuro2a (A) and 3T3L1 (D) cells before (left panel) and after (right panel) the induction of differentiation (inset; bright-field image). (B, E) Averaged Raman spectra of N2a (B) and 3T3L1 (E) cells before (blue) and after (red) induction of differentiation. Spectra are average of 15–27 cells. Spectra from the fibroblast cell-line NIH3T3 are also plotted (black). Peaks characteristic to cytochrome C are indicated with asterisks. (C, F) Score plots of Neuro2a (C) and 3T3L1 (F) cells before (blue) and after (red) the induction of differentiation calculated by PCA. For PCA analysis, raw spectra without averaging was used. Data from the fibroblast cell-line NIH3T3 are also plotted (black). Each marker shows averaged score values of the spectra obtained from single nuclei. Error bar shows SD of the score values from the same nuclei.