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. 2014 Jan 7;9(1):e84865. doi: 10.1371/journal.pone.0084865

Figure 5. Knockdown of PAH causes a reduced melanization of P. berghei ookinetes.

Figure 5

In 3 independent biological repeats dsPAH- and dsLacZ-injected (control) females were fed on a mouse infected with P. berghei parasites. Mosquito midguts were dissected and examined for oocysts 8 days after infection. A) Displayed is the proportion of females which harboured at least 1 oocyst (Likelihood of Infection: Fisher’s exact test, p>0.05) B) Oocyst load of dsPAH and dsLacZ injected females. The bars represent the mean ± SEM (Mann-Whitney U test, p>0.05). Only females with at least 1 oocyst and/or melanized ookinete were included in the analysis. C) Represented is the proportion of melanized ookinetes to the total number of oocysts per dsPAH or dsLacZ injected female. The bars indicate the mean ± SEM (t-test of arc-sine square root transformed proportion, **p<0.01).