Skip to main content
. 2014 Jan 7;9(1):e84982. doi: 10.1371/journal.pone.0084982

Figure 4. Effects of DUSP1 knockdown on cisplatin response of human pancreatic cancer cells.

Figure 4

BxPC-3 and COLO-357 cells were stably transduced with lentivirus expressing shRNA against scramble control or DUSP1. (A) Cells were incubated for 48 h in the absence or presence of varying concentrations of gemcitabine, and MTT assays were performed. Data are the means ± SEM of 3 experiments. *p<0.05; **p<0.01, compared with control. (B) BxPC-3 and COLO-357 cells were incubated with 2 µg/ml cisplatin for the indicated times, and immunoblotting was conducted.