Skip to main content
. 2014 Jan 7;9(1):e84982. doi: 10.1371/journal.pone.0084982

Figure 5. Knockdown of MKP2 does not affect JNK/p38 MAPK signaling activity or pancreatic cancer chemosensitivity to gemcitabine.

Figure 5

AsPC-1 and BxPC-3 cells were stably transduced with lentivirus expressing shRNA against scramble control or MKP2. (A) Cells were incubated for 48 h in the absence or presence of varying concentrations of gemcitabine, and MTT assays were performed. (B) AsPC-1 and BxPC-3 cells were incubated for the indicated times with 100 ng/ml and 10 ng/ml gemcitabine, respectively, and immunoblotting was conducted. Data are the means ± SEM of 3 experiments.