Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Gemcitabine activates JNK and p38 MAPK (p38) signaling, which mediates apoptotic cell death. Activated JNK and p38 MAPK then upregulate DUSP1 transcription, which negatively modulates JNK and p38 MAPK signaling activity and attenuate gemcitabine-induced cell death. Inhibiting DUSP1 in combination with gemcitabine treatment significantly enhances chemosensitivity of pancreatic cancer cells.
