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. 2013 Dec 7;5(12):867–883. doi: 10.18632/aging.100621

Figure 1. DNase I sensitivity of chromatin in intact nuclei.

Figure 1

(A) The ratio of high to low molecular weight DNA for liver nuclei was calculated following agarose gel electrophoresis (Supplemental Figure 1). Means and standard deviations are shown. (*) p<0.01, (**) p≤0.05, (see Supplemental Information; mo, months). (B) Left panels: the extent tail moment was calculated following single cell electrophoresis (see Supplemental Figure 2 for alternative quantification). Data are shown as box plots (box shows median 50% (25%-75%), whiskers the 90%-10% range, dots the 95% and 5% values (A.U., arbitrary units). Right panels: representative images of Comet assays (liver, 0.5 units DNase I, 10 min).