Table 2. Differentiation of MCI from AMC by miRNA biomarker pairs.

Family/normalizer	miRNA	AUC	Sensitivity	Specificity	Accuracy	P-value (MCI vs. AMC)
miR-132/miR-491-5p	miR-128	0.97	84%	96%	90%	3.53E-16
	miR-132	0.97	88%	98%	93%	1.60E-15
	miR-874	0.98	94%	96%	95%	3.16E-16
	3 pairs	0.98	96%	96%	96%	1.51E-16
miR-134/miR-370	miR-134	0.92	86%	82%	84%	1.55E-12
	miR-323-3p	0.92	88%	80%	84%	9.46E-13
	miR-382	0.89	76%	90%	83%	5.37E-11
	3 pairs	0.93	80%	94%	87%	2.29E-12
miR-132/370	miR-128	0.80	62%	82%	72%	7.10E-7
	miR-132	0.82	74%	76%	75%	3.57E-8
	miR-874	0.85	88%	64%	76%	1.92E-9
	3 pairs	0.83	86%	66%	76%	1.30E-8
miR-134/miR-491-5p	miR-134	0.65	36%	88%	62%	1.00E-2
	miR-323-3p	0.63	38%	88%	63%	2.08E-2
	miR-382	0.63	38%	80%	59%	2.97E-2
	3 pairs	0.65	36%	88%	62%	1.82E-2