Table 2. Serum and liver iron indices in wild type and Hjv−/− mice of 129S6/SvEvTac or C57BL/6 genetic background (n = 10 male C57BL/6 mice for each genotype; n = 5 male 129S6/SvEvTac mice for each genotype).
Genotype | wild type | wild type | Hjv−/− | Hjv−/− |
Strain | 129S6/SvEvTac | C57BL/6 | 129S6/SvEvTac | C57BL/6 |
Serum iron (µmol/L) | 34.40±2.015 | 26.20±1.597** | 56.80±3.734 | 48.50±1.682* |
Tf saturation (%) | 54.60±4.226 | 50.10±2.755 | 96.50±0.2887 | 79.14±2.219*** |
Liver iron (µg/g dry tissue) | 652.1±68.31 | 255.6±11.01*** | 7340±776.0 | 6070±411.3 |
p<0.05;
p<0.01;
p<0.001 vs 129S6/SvEvTac mice of the same genotype (Student’s t test).
All differences among wild type and Hjv−/− mice of the same strain are statistically significant (p values not shown).