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. 2014 Jan 7;9(1):e83715. doi: 10.1371/journal.pone.0083715

Figure 4. InsP3R induced Ca2+ release stimulates NCX activity.

Figure 4

Current voltage plots for INCX recorded in ESdCs under control conditions and after 3 min superfusion with either A: ET-1 (100 nmol/L; n = 8), B: ET-1 (100 nmol/L)+2-APB (2 µmol/L; n = 5), or C: caffeine (Caff: 100 µmol/L; n = 7). Currents are corrected for the nickel (5 mmol/L) insensitive background. D: Normalized INCX recorded at −80 mV. INCX recorded on superfusion with ET-1 was significantly different from Caff and ET-1+2-APB. E: Normalized change in basal [Ca2+]i. Significant increase of basal [Ca2+]i was observed upon superfusion with Caff and ET-1. F: ESdCs beating frequency after 3 min superfusion with ET-1 (n = 4) or caffeine (n = 6) respectively. *: paired t-test P<0.05; #: one way ANOVA P<0.05.