Table 3. The association of global DNA methylation with detection of AFB1-albumin adducts.
| |
|
AFB1-Alb adducts |
|
|
|
|---|---|---|---|---|---|
| % Methylation | Undetectable | Detectable | OR(95%CI) | AdjOR(95%CI) | |
| LINE-1 |
1 unit decrease |
241 |
899 |
1.00(0.93–1.07) |
1.01(0.94–1.01) |
| |
|
|
|
|
|
| |
Above mean(> 75.5) |
119 |
459 |
1.0 |
1.0 |
| |
Below mean(≤ 75.5) |
122 |
440 |
1.00(0.70–1.24) |
1.04(0.77–1.40) |
| |
Quartile |
|
|
|
|
| |
Q4 (> 76.79) |
50 |
242 |
1.0 |
1.0 |
| |
Q3 (75.50–76.79) |
69 |
217 |
0.65(0.43–0.98) |
0.61(0.40–0.93) |
| |
Q2 (74.20–75.49) |
74 |
217 |
0.61(0.41–0.91) |
0.61(0.40–0.94) |
| |
Q1(< 74.20) |
48 |
223 |
0.96(0.62–1.48) |
1.09(0.69–1.72) |
| |
|
|
|
Ptrend = 0.71 |
Ptrend = 0.75 |
| logSat2 |
1 unit decrease |
237 |
880 |
1.08(0.84–1.37) |
1.26(0.96–1.66) |
| |
|
|
|
|
|
| |
Above mean(> 4.6) |
128 |
472 |
1.0 |
1.0 |
| |
Below mean(≤ 4.6) |
113 |
427 |
1.03(0.77–1.36) |
1.17(0.87–1.58) |
| |
Quartile |
|
|
|
|
| |
Q4(> 5.0) |
62 |
219 |
1.0 |
1.0 |
| |
Q3(4.7–5.0) |
62 |
225 |
1.03(0.69–1.53) |
1.15(0.76–1.76) |
| |
Q2(4.3–4.6) |
69 |
209 |
0.86(0.58–1.27) |
1.03(0.68–1.56) |
| |
Q1(< 4.3) |
44 |
227 |
1.46(0.95–2.24) |
1.81(1.15–2.85) |
| Ptrend = 0.20 | Ptrend = 0.03 | ||||
OR adjusted for age, sex, smoking, alcohol, HBsAg status, and anti-HCV status.