Table 4. The association of global DNA methylation with of detection of urinary AFB1 metabolites.
| |
|
Urinary AFB1 |
|
|
|
|---|---|---|---|---|---|
| % Methylation | Undetectable | Detectable | OR(95%CI) | AdjOR(95%CI) | |
| LINE-1 |
1 unit decrease |
197 |
943 |
1.09(1.03–1.20) |
1.12(1.03–1.22) |
| |
|
|
|
|
|
| |
Above mean(> 75.5) |
123 |
455 |
1.0 |
1.0 |
| |
Below mean(≤ 75.5) |
74 |
488 |
1.78(1.30–2.44) |
1.75(1.25–2.44) |
| |
|
|
|
|
|
| |
Quartile |
|
|
|
|
| |
Q4 (> 76.79) |
57 |
235 |
1.0 |
1.0 |
| |
Q3 (75.50–76.79) |
66 |
220 |
0.81(0.54–1.21) |
1.03(0.67–1.56) |
| |
Q2 (74.20–75.49) |
41 |
250 |
1.48(0.95–2.29) |
1.70(1.07–2.69) |
| |
Q1(< 74.20) |
33 |
238 |
1.75(1.10–2.79) |
1.87(1.15–3.04) |
| |
|
|
|
Ptrend = 0.002 |
Ptrend = 0.004 |
| logSat2 |
1 unit decrease |
195 |
922 |
1.67(1.26–2.21) |
1.48(1.10–2.00) |
| |
|
|
|
|
|
| |
Above mean(> 4.6) |
120 |
480 |
1.0 |
1.0 |
| |
Below mean(≤ 4.6) |
77 |
463 |
1.50(1.10–2.06) |
1.36(0.98–1.90) |
| |
Quartile |
|
|
|
|
| |
Q4(> 5.0) |
62 |
219 |
1.0 |
1.0 |
| |
Q3(4.7–5.0) |
51 |
236 |
1.31(0.87–1.98) |
1.33(0.85–2.07) |
| |
Q2(4.3–4.6) |
47 |
231 |
1.39(0.91–2.12) |
1.26(0.80–1.97) |
| |
Q1(< 4.3) |
35 |
236 |
1.91(1.21–3.00) |
1.75(1.08–2.82) |
| Ptrend = 0.006 | Ptrend = 0.03 | ||||
OR adjusted for age, sex, smoking, alcohol, HBsAg status, and anti-HCV status.