Table 2.

Adjusted Odds Ratios (95% Confidence Intervals) of Having Leptin and Resistin Levels in the Top Tertile, and Adiponectin Levels in the Bottom Tertile, Associated with Body Size Phenotypes

	Top Tertile of Leptin (21.0–138.6 ng/ml)			Top Tertile of Resistin (14.2–182.6 ng/ml)			Bottom Tertile of Adiponectin ( 0.0–21.8 μg/ml)
	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
MBNW (n=372)	1.00	(reference)		1.00	(reference)		1.00	(reference)
ARNW (n=310)	2.53	1.28–5.01	0.008	1.39	0.98–1.95	0.064	2.64	1.81–3.84	<0.001
MBO (n=319)	16.84	9.24–30.68	< 0.001	1.55	1.11–2.18	0.011	1.46	0.98–2.16	0.062
ARO (n=844)	27.03	15.22–48.00	< 0.001	1.78	1.34–2.38	<0.001	4.08	2.95–5.65	< 0.001

Model 1 = adjusted for age, race, stroke case status, smoking, physical activity, and hormone therapy use

MBNW – Metabolically Benign Normal Weight; ARNW – At-Risk Normal Weight; MBO – Metabolically Benign Overweight/Obese; ARO – At-Risk Overweight/Obese

The Metabolically Benign Phenotype was defined as ≤1 of: elevated blood pressure (≥130/85 mmHg or medication), elevated triglycerides (≥150mg/dL), elevated fasting glucose (≥100 mg/dL or medication), low HDL-C (<50mg/dL for women or medication).

The Metabolically At-Risk Phenotype was defined as ≥ 2 of: elevated blood pressure (≥130/85 mmHg or medication), elevated triglycerides (≥150mg/dL), elevated fasting glucose (≥100 mg/dL or medication), low HDL-C (<50mg/dL for women or medication). OR If diabetic (self-report of diabetes, fasting blood glucose ≥ 126 mg/dl or on antidiabetic medication).