Table 4.

Adjusted Odds Ratios (95% Confidence Intervals) of Having Leptin and Resistin Levels in the Top Tertile, and Adiponectin Levels in the Bottom Tertile, Associated with Body Size Phenotypes

	Top Tertile of Leptin (21.0–138.6 ng/ml)			Top Tertile of Resistin (14.2–182.6 ng/ml)			Bottom Tertile of Adiponectin ( 0.0–21.8 μg/ml)
	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
Model 1
MBO (n= 319)	1.00	(reference)		1.00	(reference)		1.00	(reference)
ARO (n= 844)	1.62	1.24–2.12	< 0.001	1.12	0.85–1.48	0.429	2.78	2.04–3.77	< 0.001
Model 2
MBO	1.00	(reference)		1.00	(reference)		1.00	(reference)
ARO	1.22	0.91–1.62	0.180	1.02	0.77–1.36	0.876	2.60	1.91–3.55	< 0.001

Model 1 = adjusted for age, race, stroke case status, smoking, physical activity, and hormone therapy use

Model 2 = Model 1 + BMI

MBO – Metabolically Benign Overweight/Obese Phenotype; ARO – At-Risk Overweight/Obese Phenotype

The Metabolically Benign Phenotype was defined as ≤ 1 of: elevated blood pressure (≥130/85 mmHg or medication), elevated triglycerides (≥150mg/dL), elevated fasting glucose (≥100 mg/dL or medication), low HDL-C (<50mg/dL for women or medication).

The Metabolically At-Risk Phenotype was defined as ≥ 2 of: elevated blood pressure (≥130/85 mmHg or medication), elevated triglycerides (≥150mg/dL), elevated fasting glucose (≥100 mg/dL or medication), low HDL-C (<50mg/dL for women or medication). OR If diabetic (fasting blood glucose ≥ 126 mg/dl, or self-report of diabetes or on antidiabetic medication).