. Author manuscript; available in PMC: 2014 Jan 8.

Published in final edited form as: Genet Med. 2013 Jun 27;16(1):10.1038/gim.2013.80. doi: 10.1038/gim.2013.80

Table 3.

Illustration of predictive ability using risk categories that 23andMe uses to classify disease risks

Diseases		23andMe			deCODEme			Navigenics
Diseases		↓	-	↑	↓	-	↑	↓	-	↑
Age-related macular degeneration	Patients	26.7	1.7	71.2	23.0	13.0	64.0	18.2	11.6	70.2
Age-related macular degeneration	NonPatients	66.7	2.1	31.2	69.2	13.2	17.6	66.5	10.5	23.0

Atrial fibrillation	Patients	53.1	14.4	32.5	34.1	33.1	32.9	52.6	14.2	33.2
Atrial fibrillation	NonPatients	66.3	12.5	21.2	49.5	33.4	17.1	65.9	13.0	21.2

Celiac disease	Patients	42.1	0.0	57.9	22.9	2.5	74.6	24.6	4.9	70.5
Celiac disease	NonPatients	80.6	1.1	18.3	75.4	2.8	21.8	75.7	4.9	18.4

Crohn disease	Patients	31.2	10.1	58.7	39.7	10.9	49.4	26.7^a	15.1^a	58.3^a
Crohn disease	NonPatients	69.7	10.9	19.4	83.8	5.5	10.7	65.6^a	13.0^a	21.5^a

Prostate cancer	Patients	17.5	33.3	49.3	23.3	22.1	48.6	25.8	38.4	35.9
Prostate cancer	NonPatients	29.7	36.3	34.0	54.1	21.7	24.2	38.4	38.8	22.9

Type 2 diabetes	Patients	23.0	43.5	33.5	29.3	26.9	43.8	31.3^a	31.2^a	37.5^a
Type 2 diabetes	NonPatients	33.5	43.7	22.8	48.4	27.2	24.5	48.4^a	31.5^a	20.1^a

23andMe categorizes disease risks as decreased (↓), elevated (↑), and typical (-) risks if the risks of disease are lower than 20% below the average population risk, higher than 20% above the average population risk, and in between, respectively. Values are percentages.

Calculated using an approximation of the formula described by Navigenics in their white paper (see Supplementary Materials and Methods online).