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. Author manuscript; available in PMC: 2014 Nov 11.
Published in final edited form as: Small. 2013 May 8;9(21):3704–3713. doi: 10.1002/smll.201202075

Figure 5.

Figure 5

A) H&E micrographs of human cadaver skin treated with cone shaped silk MN, (i) MN loaded with microparticles and no post treatment, (ii) MN with no microparticles and post treatment with water vapor and (iii) MN loaded with microparticles and post treated with water vapor. B) Sulforhodamine released into the skin from the cone shaped silk MN loaded with the microparticles and no further post fabrication treatment. C) and D) Sulforhodamine released into human cadaver skin from MN patch with no post fabrication treatment and water vapor annealing treatment, respectively. The needles contained no microparticles. E) Human cadaver skin treated with the control patch (silk film without microneedles).