Table 2.
Summary of relative changes in gene expression levels for VFFs and BM-MSCs during monoculture and after co-culture
Collagen I | Collagen III | MMP1 | TIMP3 | VEGF | HGF | IL-6 | |
---|---|---|---|---|---|---|---|
Monocultured normal VFFs control | |||||||
Monocultured scarred VFFs | ▲* | ▲** | ▲** | ▲* | ▼* | ▼* | ▲** |
Monocultured normal VFFs control | |||||||
Co-cultured normal VFFs with BM-MSCs | — | ▼* | ▲* | — | ▲* | ▲** | — |
Monocultured scarred VFFs control | |||||||
Co-cultured scarred VFFs with BM-MSCs | ▲* | ▼* | ▲** | ▲* | ▲** | ▲** | ▼* |
Monocultured BM-MSCs control | |||||||
Co-cultured BM-MSCs with normal VFFs | ▲** | — | — | ▼* | ▼** | ▲** | ▼** |
Co-cultured BM-MSCs with scarred VFFs | — | ▲** | ▲** | — | ▼* | ▲** | ▼* |
▲, Upregulation
▼, downregulation
—, no significant change
p <0.05
p <0.01.