Table 7.
Analysis results of Baylor AD dataset under various models.
Naive
|
M1
|
M2
|
||||
---|---|---|---|---|---|---|
PMSD | 95% CI | PMSD | 95% CI | PMSD | 95% CI | |
Outcome model | ||||||
Int | 0.683.353 | −0.008, 1.374 | −0.044.551 | −1.200, 0.946 | −0.7011.141 | −3.831, 0.891 |
x | 1.881.320 | 1.254, 2.507 | 2.674.520 | 1.762, 3.838 | 3.5391.180 | 1.887, 6.758 |
Pre-prog | −1.347.184 | −1.707, −0.987 | −1.681.241 | −2.174, −1.222 | −1.796.298 | −2.431, −1.258 |
Age | −0.136.114 | −0.360, 0.088 | −0.175.148 | −0.472, 0.104 | −0.113.216 | −0.491, 0.387 |
IQ | 0.606.116 | 0.379, 0.834 | 0.917.158 | 0.616, 1.241 | 0.868.212 | 0.445, 1.291 |
Exposure model | ||||||
Int | 2.788.264 | 2.271, 3.304 | 2.864.278 | 2.347, 3.430 | 2.797.389 | 2.055, 3.598 |
Pre-prog | −0.603.200 | −0.996, −0.211 | −0.623.209 | −1.034, −0.224 | −0.719.259 | −1.267, −0.245 |
Age | −0.404.141 | −0.679, −0.128 | −0.412.146 | −0.711, −0.130 | −0.508.202 | −0.943, −0.155 |
IQ | 0.687.135 | 0.422, 0.953 | 0.680.140 | 0.406, 0.955 | 0.859.225 | 0.482, 1.370 |
MMSE | ||||||
p | 0.974.014 | 0.942, 0.997 | 0.973.017 | 0.934, 0.998 | ||
q | 0.793.046 | 0.702, 0.881 | 0.771.052 | 0.666, 0.870 | ||
ADAS | ||||||
p | 0.815.027 | 0.762, 0.869 | 0.809.029 | 0.752, 0.865 | ||
q | 0.906.029 | 0.845, 0.960 | 0.883.038 | 0.803, 0.951 | ||
CDR-Total | ||||||
p | 0.993.005 | 0.980, 1.000 | 0.986.010 | 0.962, 0.999 | ||
q | 0.982.017 | 0.936, 1.000 | 0.786.142 | 0.566, 0.996 | ||
CDR-SB | ||||||
p | 0.997.003 | 0.990, 1.000 | 0.989.008 | 0.969, 0.999 | ||
q | 0.834.049 | 0.732, 0.923 | 0.664.118 | 0.504, 0.876 |
Naive: naive analysis which ignores misclassification and treats y1 and x1 as y and x, respectively; M1: the model assuming conditional independence in both measurements of y and x; M2: the model assuming conditional dependence in both measurements of y and x; pre-prog: log pre-progression rate; age: standardized age; IQ: standardized premorbid IQ; CI: Credible interval; MMSE: Mini-Mental Status Exam; ADAS: Alzheimers Disease Assessment Scale-Cognitive Subscale; CDR-Total: Clinical Dementia Rating Scale-Total; and CDR-SB: Clinical Dementia Rating Scale-Sum of Boxes.