Table 3.

Association between tagSNPs in the TNF region and vulvar cancer risk, Seattle-Puget Sound Region, 1986–2004.

SNPs	MAF Controls (N=1,100) (%)	All vulvar cancer				Vulvar cancer (HPV +)				Vulvar cancer (HPV -)
		MAF Cases (N=517) (%)	OR*	(95% CI) *	Adj. P‡	MAF Cases (N=403) (%)	OR*	(95% CI) *	Adj. P‡	MAF Cases (N=473) (%)	OR*	(95% CI) *	Adj. P‡
rs2009658	17.12	13.09	0.72	(0.58–0.90)	0.652	12.79	0.70	(0.55–0.90)	1.000	16.67	0.93	(0.60–1.45)	1.000
rs915654	36.25	28.38	0.70	(0.59–0.82)	3.2×10−3	27.09	0.65	(0.54–0.79)	2.2×10−3	33.33	0.87	(0.61–1.22)	1.000
rs2239704	37.65	47.95	1.51	(1.30–1.75)	1.9×10−5	49.00	1.58	(1.33–1.87)	5.1×10−5	42.95	1.24	(0.89–1.73)	1.000
rs2229094	27.92	22.32	0.74	(0.62–0.88)	0.172	21.63	0.71	(0.58–0.87)	0.216	26.92	0.96	(0.66–1.39)	1.000
rs2229092	6.95	5.31	0.75	(0.54–1.03)	1.000	5.86	0.83	(0.58–1.19)	1.000	5.77	0.81	(0.41–1.62)	1.000
rs1799964	23.08	18.71	0.76	(0.63–0.92)	1.000	18.77	0.77	(0.62–0.96)	1.000	20.51	0.86	(0.57–1.29)	1.000
rs1800610	7.53	10.53	1.44	(1.12–1.86)	0.974	10.17	1.38	(1.04–1.85)	1.000	8.97	1.22	(0.70–2.13)	1.000
rs3093662	7.95	7.02	0.88	(0.66–1.18)	1.000	7.16	0.90	(0.64–1.26)	1.000	5.77	0.76	(0.38–1.54)	1.000
rs769178	7.26	10.72	1.53	(1.18–1.97)	0.233	10.46	1.48	(1.11–1.97)	1.000	8.97	1.27	(0.73–2.20)	1.000
rs2256965	40.26	49.41	1.43	(1.23–1.66)	5.5×10−4	50.29	1.48	(1.25–1.76)	1.4×10−3	47.44	1.32	(0.95–1.83)	1.000
rs1052248	29.45	24.07	0.76	(0.64–0.91)	0.414	23.35	0.73	(0.60–0.89)	0.465	27.56	0.92	(0.64–1.33)	1.000
rs11575839	2.47	2.33	0.95	(0.57–1.57)	1.000	2.69	1.09	(0.63–1.90)	1.000	0.65	0.25	(0.03–1.86)	1.000

MAF: Minor allele frequency.

^*Age-adjusted OR assuming an additive model.

^‡P value adjusted for multiple testing using the Bonferroni adjustment across all 205 SNPs. Bold indicates significant at the adjusted 5% level.