Table 2.
SNPs most strongly associated (top 20 shown) with PTSD in trauma-exposed individuals (N=1749) – additive models controlling for case status and sex
| Gene | SNP | Chr | SNP Location* | MA | p Value^ | Odds Ratio |
|---|---|---|---|---|---|---|
| DRD2 | rs12364283 | 11 | 112852165 | G | .00014 | 1.66 |
| DRD2 | rs12805897 | 11 | 112829503 | A | .00029 | 1.63 |
| TH | rs10840491 | 11 | 2150966 | A | .0012 | 1.39 |
| TH | rs10840490 | 11 | 2150393 | G | .0029 | 1.35 |
| ARRB1 | rs7929974 | 11 | 74706815 | A | .0054 | 0.82 |
| ITGA6 | rs7604404 | 2 | 173016564 | A | .0063 | 0.76 |
| SLC6A3 | rs6869645 | 5 | 1457548 | GA | .0076 | 1.22 |
| DRD3 | rs6787134 | 3 | 115385439 | C | .0088 | 0.80 |
| NCAM1 | rs6589363 | 11 | 112559644 | A | .0097 | 1.25 |
| NCAM1 | rs1245119 | 11 | 112506871 | C | .011 | 1.22 |
| GABRG3 | rs12592749 | 15 | 25415996 | A | .012 | 1.39 |
| GRIN2A | rs3859123 | 16 | 9978396 | G | .014 | 1.20 |
| GRIN2A | rs7200719 | 16 | 10002047 | A | .014 | 1.35 |
| intergenic | rs265983 | 5 | 174767723 | T | .015 | 0.82 |
| GRIN2A | rs9933111 | 16 | 10072100 | G | .015 | 1.35 |
| DBH | rs2519154 | 9 | 135502096 | G | .016 | 0.84 |
| TPH1 | rs17794760 | 11 | 18012496 | A | .017 | 1.25 |
| GRIN2B | rs10845847 | 12 | 13912004 | A | .017 | 0.84 |
| DRD2 | rs4648317 | 11 | 112836742 | A | .018 | 1.26 |
| NRXN3 | rs12147956 | 14 | 79232192 | G | .019 | 0.75 |
*
NCBI build 37.2; Chr = chromosome; MA = minor allele;
^
not adjusted for multiple testing