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. Author manuscript; available in PMC: 2014 Sep 5.
Published in final edited form as: Free Radic Biol Med. 2013 Mar 5;0:179–196. doi: 10.1016/j.freeradbiomed.2013.02.006

Table 1.

Effect of lactational exposure to CrIII on circulating levels of estradiol, testosterone, progesterone and FSH in F1 rats on postnatal days 25, 45 and 65.

Age Treatment Hormone profile
Estradiol (pg/ml) Testosterone (pg/ml) Progesterone (ng/ml) FSH (ng/ml)
PND 25 Control 30.2 ± 2.0 923 ± 69 5.3 ± 3.1 14.2 ± 1.0
Cr 50ppm 21.3 ± 1.3a 615 ± 45a 1.2 ± 2.0a 29.5 ± 2.1a
Cr 50ppm + Vit. C 28.4 ± 1.8b 856 ± 69b 4.5 ± 2.0b 15.4 ± 0.7b
Control 30.2 ± 2.0 923 ± 69 5.3 ± 3.1 14.2 ± 1.0
Cr 100ppm 15.1 ± 0.7a 548 ± 41a 1.5 ± 2.0a 32.4 ± 2.3a
Cr 100 ppm + Vit. C 27.9 ± 2.2b 825 ± 48b 4.0 ± 2.0b 21.2 ± 1.6b
Control 30.2 ± 2.0 923 ± 69 5.3 ± 3.1 14.2 ± 1.0
Cr 200 ppm 12.5 ± 0.8a 359 ± 29a 0.7 ± 0.05a 35.3 ± 2.3a
Cr 200 ppm + Vit. C 22.4 ± 1.5ab 656 ± 48ab 2.0 ± 0.09ab 21.4 ± 1.6b
PND 45 Control 40.3 ± 2.0 950 ± 86 6.9 ± 0.4 14.2 ± 1.2
Cr 50 ppm 21.3 ± 1.4a 610 ± 32a 3.0 ± 0.2a 27.4 ± 2.0a
Cr 50 ppm + vitamin C 41.2 ± 3.0b 913 ± 82b 8.5 ± 0.7b 16.3 ± 1.0b
Control 40.3 ± 2.0 950 ± 86 6.9 ± 0.4 14.2 ± 1.2
Cr 100 ppm 12.4 ± 1.0a 620 ± 35a 2.8 ± 0.1a 30.2 ± 2.0a
Cr 100 ppm + Vit. C 41.5 ± 3.1b 847 ± 69b 7.2 ± 0.5b 13.5 ± 1.0b
Control 40.3 ± 2.0 950 ± 86 6.9 ± 0.4 14.2 ± 1.2
Cr 200 ppm 12.2 ± 0.9a 390 ± 38a 1. 0 ± 0.05a 35.3 ± 2.1a
Cr 200 ppm + Vit. C 28.5 ± 1.9ab 725 ± 40ab 7.3 ± 0.4b 15.5 ± 1.1b
PND 65 Control 42.2 ± 3.4 950 ± 52 9.8 ± 0.6 13.8 ± 1.0
Cr 50 ppm 28.4 ± 2.1a 717 ± 42a 5.4 ± 0.3a 25.4 ± 1.6a
Cr 50 ppm + vitamin C 41.5 ± 2.5b 850 ± 53b 9.2 ± 0.5b 14.3 ± 0.9b
Control 42.2 ± 3.4 950 ± 52 9.8 ± 0.6 13.8 ± 1.0
Cr 100 ppm 28.2 ± 2.1a 719 ± 67a 3.5 ± 2.0a 32.4 ± 3.0a
Cr 100 ppm + Vit. C 43.4 ± 2.0b 870 ± 69b 8.2 ± 2.0b 19.5 ± 1.4b
Control 42.2 ± 3.4 950 ± 52 9.8 ± 0.6 13.8 ± 1.0
Cr 200 ppm 18.3 ± 1.4a 585 ± 46a 3.4 ± 0.1a 35.1 ± 2.2a
Cr 200 ppm + Vit. C 39.7 ± 2.4b 909 ± 78b 6.3 ± 0.4ab 17.6 ± 1.2b

p<0.05. Each value represents mean ± SEM of 20 female rats (from 5 mothers). See materials and methods for experimental details. PND – Postnatal day.

a

Control vs Cr or Cr+ vitamin C.

b

Crvs Cr+ vitamin C.