Fig. 4.

Tolerogenic function of HLA-G α₁–α₃ structure (α₁–α₃-Fc) in vivo. C57BL/6 mice strongly recognize the MHC class II-disparate mutant bm12 mouse that carries the I-A^bm12 alloantigen. The capability of α₁–α₃-Fc-coated beads to delay rejection was evaluated with non-transgenic and LILRB2-transgenic recipient animals. Kaplan–Meier curves representing graft survival are shown for α₁–α₃-Fc (plain lines) and control treatment (dotted lines). Control treatment: beads coated with mAb but without α₁–α₃-Fc. Results are expressed as median of graft survival time. Associated values are indicated above the curves