Table 1.
Prevalence of Knee Magnetic Resonance Imaging Findings and Average Serum Leptin Levels at Baseline and Follow-Up Visit 7 According to Magnetic Resonance Imaging-Defined Knee Cartilage Defects, Bone Marrow Lesions, Osteophytes, Meniscal Tears, Synovitis, and Joint Effusions Among Michigan Study of Women’s Health Across the Nation (SWAN) Women at Follow-Up Visit 11.
| Overall (n=364) |
Baseline Leptin (ng/mL) |
Visit 7 Leptin (ng/mL) |
|
|---|---|---|---|
| Cartilage defects | N (%) | Mean (SD) | Mean (SD) |
| Normal, internal signal alteration only | 8 (2.2%) | 14.9 (5.7) | 27.0 (9.1) |
| Cartilage defect < 50% thickness | 143 (39.3%) | 27.4 (16.1) | 33.5 (19.1) |
| Cartilage defect 50–99% thickness | 127 (34.9%) | 31.3 (17.4) | 37.1 (19.4) |
| Cartilage defect 100% thickness | 86 (23.6%) | 40.2 (20.4) | 47.1 (22.6) |
| P-value* | <0.0001 | <0.0001 | |
| Bone marrow lesions (BML) | |||
| Normal | 215 (59.1%) | 27.6 (16.6) | 35.0 (19.8) |
| Largest diameter ≤ 1 cm | 104 (28.6%) | 36.6 (19.9) | 40.4 (20.5) |
| Largest diameter > 1 cm | 45 (12.4%) | 37.4 (17.9) | 45.9 (22.8) |
| P-value* | <0.0001 | 0.005 | |
| Osteophytes | |||
| None | 74 (20.3%) | 21.5 (16.2) | 28.8 (17.7) |
| ≤ 5 mm | 174 (47.8%) | 29.5 (15.1) | 34.3 (18.2) |
| 5–10 mm | 82 (22.5%) | 38.7 (20.6) | 46.2 (21.1) |
| > 10 mm | 34 (9.3%) | 45.9 (16.6) | 56.5 (20.6) |
| P-value* | <0.0001 | <0.0001 | |
| Meniscal abnormalities/tears | |||
| Normal | 18 (5.0%) | 27.7 (16.5) | 40.8 (19.8) |
| Intrasubstance meniscal abnormality only | 157 (43.1%) | 27.4 (17.2) | 31.9 (18.2) |
| Non-displaced tear | 77 (21.2%) | 33.7 (17.3) | 40.1 (21.2) |
| Displaced or macerated tear | 112 (30.8%) | 36.3 (19.4) | 44.6 (21.7) |
| P-value* | 0.0007 | <0.0001 | |
| Synovitis | |||
| Normal | 241 (66.2%) | 27.5 (16.3) | 34.3 (19.8) |
| Mild synovitis | 90 (24.7%) | 37.6 (18.4) | 43.3 (19.5) |
| Moderate-to-marked synovitis | 33 (9.1%) | 44.0 (21.9) | 48.4 (23.9) |
| P-value* | <0.0001 | <0.0001 | |
| Effusion | |||
| Physiologic fluid | 61 (16.8%) | 24.5 (15.8) | 29.3 (16.5) |
| Small effusion (≤ 10 mm) | 253 (69.5%) | 29.6 (15.9) | 37.5 (20.8) |
| Moderate and/or large effusion (> 10 mm) | 50 (13.7%) | 48.8 (21.7) | 50.6 (18.9) |
| P-value* | <0.0001 | <0.0001 | |
*
All p-values are based on global F-test from ANOVA which tests hypothesis that all means across severity groups are equal.