Table VI.
Associations between maternal ADH1B genotype and childhood atopic outcomes stratified by reported alcohol intake during the last 2 mo of pregnancy
| Outcome by ADH1B genotype | Mother’s alcohol intake (units/wk) never |
Mother’s alcohol intake (units/wk) ≥1 |
||
|---|---|---|---|---|
| No. | Adjusted estimate∗ (95% CI) | No. | Adjusted estimate∗ (95% CI) | |
| Asthma† | ||||
| G:G | 2001 | 1.0 | 2372 | 1.0 |
| G:A/A:A | 121 | 0.94 (0.53-1.68) | 103 | 1.14 (0.62-2.10) |
| Total | 4597 | |||
| Wheezing‡ | ||||
| G:G | 2024 | 1.0 | 2400 | 1.0 |
| G:A/A:A | 124 | 1.26 (0.72-2.19) | 105 | 0.87 (0.43-1.73) |
| Total | 4653 | |||
| Eczema§ | ||||
| G:G | 2018 | 1.0 | 2397 | 1.0 |
| G:A/A:A | 121 | 0.89 (0.52-1.52) | 105 | 1.23 (0.75-2.02) |
| Total | 4641 | |||
| Hay fever‖ | ||||
| G:G | 2017 | 1.0 | 2388 | 1.0 |
| G:A/A:A | 124 | 0.98 (0.52-1.87) | 104 | 1.23 (0.62-2.46) |
| Total | 4633 | |||
| Atopy¶ | ||||
| G:G | 1538 | 1.0 | 1894 | 1.0 |
| G:A/A:A | 102 | 1.29 (0.80-2.09) | 83 | 1.12 (0.65-1.95) |
| Total | 3617 | |||
| IgE∗∗ | ||||
| G:G | 1191 | 1.0 | 1557 | 1.0 |
| G:A/A:A | 85 | 1.23 (0.85-1.78) | 70 | 0.91 (0.61-1.36) |
| Total | 2903 | |||
GMR, Geometric mean ratio.
∗
Estimates (OR [GMR for IgE analysis]) are adjusted for all confounders listed in Methods section.
†
P for interaction = .664.
‡
P for interaction = .411.
§
P for interaction = .384.
‖
P for interaction = .636.
¶
P for interaction = .710.
∗∗
P for interaction = .288.