Table A2.
The list of Gene Ontology Molecular Function (GOMF) terms that are significant in asthma pathogenesis, as evident from the biomarkers identified by genomics, proteomics and epigenomics approaches.
| Name of the GOMF terms | Total entities | Expanded number of entities | Overlap | Percent overlap | Overlapping entities | p-value | (−logP) |
|---|---|---|---|---|---|---|---|
| Cytokine activity | 217 | 217 | 13 | 5 | Ccl8, Cxcl15, CCL11, IL13, IL9, IL4, IL2, IL10, CCL21, IFNA1, INHBA, INHA, SCGB3A1 | 3.30E–13 | 12.48204 |
| Growth factor activity | 198 | 198 | 8 | 4 | IL9, IL4, TGFB1, IL2, INHBA, VEGFC, INHA, TFF2 | 3.10E–07 | 6.509308 |
| Arginase activity | 2 | 2 | 2 | 100 | ARG1, ARG2 | 1.08E–05 | 4.967132 |
| Hematopoietin-interferon-class (D200-domain) cytokine receptor binding | 47 | 47 | 4 | 8 | IL13, IL9, IL4, IFNA1 | 1.78E–05 | 4.750718 |
| Chemokine activity | 56 | 56 | 4 | 7 | Ccl8, Cxcl15, CCL11, CCL21 | 3.57E–05 | 4.446842 |
| Protein binding | 7274 | 7274 | 41 | 0 | Muc5ac, Serpinb3c, Apoa1, ACSL3, Igh-6, IGHG1, PTGS2, EGFR, ORM1, IL13, IL4, TGFB1, IL2, IL10, CTLA4, NOS2A, SERPINA1, SOCS1, SOD1, ARG2, APOB, CYBB, TIMP4, FCGR2B, POSTN, FOXP3, CDH11, INHA, S100A9, SOCS3, TYROBP, VIM, TCF21, FBN1, C4BPA, AATF, SCNN1G, HSPA1B, ITIH1, LCN1, GNB2 | 7.37E–05 | 4.132694 |
| Protein heterodimerization activity | 268 | 268 | 6 | 2 | EGFR, TGFB1, INHBA, APOB, CYBB, INHA | 0.000265 | 3.576101 |
| Metallopeptidase activity | 178 | 178 | 5 | 2 | CPA4, MMP12, ADAM33, ACE, ADAM8 | 0.000314 | 3.502791 |
| Complement binding | 9 | 9 | 2 | 22 | CFB, C4BPA | 0.000383 | 3.417369 |
| Chitinase activity | 11 | 11 | 2 | 18 | Chi3l3, CHIA | 0.000582 | 3.235176 |
| High-density lipoprotein binding | 11 | 11 | 2 | 18 | Apoa1, PON1 | 0.000582 | 3.235176 |
| Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines | 11 | 11 | 2 | 18 | ARG1,ARG2 | 0.000582 | 3.235176 |
| Endopeptidase inhibitor activity | 118 | 118 | 4 | 3 | SERPINA1, SERPINB2, CSTA, ITIH1 | 0.000639 | 3.194323 |
| Protein binding, bridging | 60 | 60 | 3 | 5 | DSP, CSTA, COL11A1 | 0.001039 | 2.983192 |
| Peptidase activity | 633 | 633 | 8 | 1 | Slpi, CPA4, MMP12, SERPINA1, ADAM33, ACE, CFB, ADAM8 | 0.001171 | 2.93128 |
| Phospholipid binding | 64 | 64 | 3 | 4 | Apoa1, PON1, APOB | 0.001254 | 2.901838 |
| Cholesterol transporter activity | 16 | 16 | 2 | 12 | Apoa1, APOB | 0.001256 | 2.901021 |
| Serine-type endopeptidase inhibitor activity | 150 | 150 | 4 | 2 | Serpinb3c, SERPINA1, SERPINB2, ITIH1 | 0.001558 | 2.807388 |
| Antioxidant activity | 20 | 20 | 2 | 10 | PRDX6, SOD1 | 0.001972 | 2.705175 |
| Antigen binding | 79 | 79 | 3 | 3 | Igh-2, Igh-6, IGHG1 | 0.002296 | 2.63899 |
The data was generated using Pathway studio 7.1, Ariadane Genomics, Rockville, MD, USA. The column names are: Name of the GOMF terms; Total entities; expanded entities; overlap; percent overlap; overlapping entities; p-value and −log10 p-value.