Table 2.
Patient demographics, operative and treatment characteristics for patients who received postoperative chemotherapy with known timing.
| Patient Characteristics | Adjuvant therapy <8 wks (n = 110) | Adjuvant therapy ≥8 wks (n= 55) | |
|---|---|---|---|
| n (%) | n (%) | P | |
| Age (y) | |||
| Median | 55 | 54 | |
| Range | 29–83 | 35–78 | |
| Age ≤65 y | 86 (78) | 42 (76) | 0.79 |
|
| |||
| Gender | |||
|
| |||
| Male | 68 (62) | 33 (60) | |
| Female | 42 (47) | 22 (40) | 0.82 |
|
| |||
| Comorbidity* | 56 (51) | 32 (58) | 0.38 |
|
| |||
| Stage at diagnosis | |||
| I | 14 (13) | 3 (5) | |
| II | 27 (25) | 15 (27) | |
| III | 50 (45) | 24 (44) | |
| IV | 15 (14) | 9 (16) | |
| Unknown | 4 (4) | 4 (7) | 0.52 |
|
| |||
| Pathologic Stage | |||
| 0 | 19 (17) | 13 (24) | |
| I | 26 (24) | 16 (29) | |
| II | 21 (19) | 5 (9) | |
| III | 39 (35) | 19 (35) | |
| IV | 5 (5) | 2 (4) | 0.46 |
|
| |||
| Margin Status | |||
| Negative | 99 (90) | 50 (91) | |
| Positive | 11 (10) | 5 (9) | 0.85 |
|
| |||
| Chemotherapy Indicated | |||
| Yes | 83 (75) | 40 (73) | |
| No | 25 (23) | 13 (24) | |
| Unknown | 2 (2) | 2 (4) | 0.76 |
|
| |||
| Operation | |||
| LAR | 88 (80) | 41 (75) | |
| APR | 22 (20) | 14 (25) | 0.42 |
| Open | 77 (70) | 41 (75) | |
| Laparoscopic | 28 (25) | 12 (22) | |
| HALS | 5 (5) | 2 (4) | |
| Robotic | 0 (0) | 0 (0) | 0.83 |
|
| |||
| Radiation | |||
| Preoperative | 82 (75) | 39 (71) | |
| Postoperative | 14 (13) | 6 (11) | |
| Pre and postop | 4 (4) | 3 (5) | |
| None | 10 (9) | 7 (13) | 0.82 |
|
| |||
| Complications | 27 (25) | 24 (44) | 0.01 |
| Grade I+ | 14 | 9 | |
| Grade II | 9 | 7 | |
| Grade III | 3 | 8 | |
| Grade IV | 1 | 0 | |
| Grade V | 0 | 0 | |
|
| |||
| Reoperation | 4 (4) | 6 (11) | 0.07 |
|
| |||
| Length of Stay (days) | |||
| 0–4 | 21 (19) | 12 (22) | |
| 5–7 | 62 (56) | 21 (38) | |
| ≥8 | 27 (25) | 22 (40) | 0.06 |
|
| |||
| Hospital Readmission | 5 (5) | 11 (20) | 0.002 |
|
| |||
| Discharge Disposition | |||
| Skilled facility | 1 (1) | 1 (2) | |
| Home with assistance | 9 (8) | 7 (15) | |
| Home | 100 (91) | 47 (85) | 0.56 |
Comorbidity indicates the presence of any of the following comorbid conditions: diabetes mellitus, smoking, dyspnea, pre-operative functional status, ventilator dependency, chronic obstructive pulmonary disease, ascites within 30 days prior to surgery, congestive heart failure within 30 days prior to surgery, antihypertensive medications, acute renal failure, hemodialysis dependence, disseminated cancer, open wound, steroid/immunosuppressive medication use, body weight loss >10% in 6 months prior to surgery, bleeding disorder, transfusion of red blood cells within 72 hours prior to surgery, and sepsis within 48 hours prior to surgery.
Complications graded using Clavien-Dindo Classification16