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Expression of NAMPT and NAPRT1 in tumor xenografts after treatment with NA. NAMPT and NAPRT1 protein expression was determined in PC3 (A), HT-1080 (B), and MiaPaCa-2 (C) tumor xenografts after 5 days of treatment with vehicle control, 100 mg/kg NA, 30 mg/kg GNE-617, or the combination of both agents by Western blot analysis as described in Materials and Methods section (n = 4 animals per group). Colo205 tumor cell lysates were included as positive controls for NAPRT1 expression.
