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N-Myc alters MXI1-0 and MXI1 promoter activities. SHEP cells were transfected with an MXI1-0 or MXI1 luciferase reporter plasmid (p3B/MXI1-0 and p3B/MXI1, respectively) and a Renilla reniformis luciferase plasmid (pRL-TK, internal control). Varying amounts of a MYCN expression plasmid (pCMV MYCN) were also transfected into these cells. After 48 hours, the mean luciferase activity (luciferase/Renilla) was determined. *P < .05 when compared to no MYCN.
