Table II.
Interval | All
|
Men
|
Women
|
Heritability
|
|||
---|---|---|---|---|---|---|---|
N* | Mean (SD) | N* | Mean (SD) | N* | Mean (SD) | h2 (SE)† | |
QT, milliseconds | 4062 | 413.8 (31.1) | 1531 | 408.5 (30.6) | 2531 | 417.0 (30.9) | 0.43 (0.07) |
QTc, milliseconds | 4062 | 425.6 (26.3) | 1531 | 414.7 (25.8) | 2531 | 432.1 (24.3) | N/A |
JT, milliseconds | 4062 | 321.0 (30.9) | 1531 | 312.2 (29.8) | 2531 | 326.3 (30.3) | 0.42 (0.06) |
JTc, milliseconds | 4062 | 332.8 (27.0) | 1531 | 318.4 (25.6) | 2531 | 341.5 (24.0) | N/A |
QRS, milliseconds | 4212 | 92.9 (11.7) | 1578 | 96.5 (12.3) | 2634 | 90.7 (10.8) | 0.33 (0.06) |
h2 = heritability coefficient; JTc = QTc – QRS; N/A = not applicable.
Total number in each group with an SCN5A-1103S/1103Y genotype after the interval-specific exclusions.
The heritability was estimated in 1494 JHS participants in 266 families using variance components methods implemented in SOLAR34 and represents the fraction of remaining variation (after adjustment for covariates) explained by additive genetic factors.