. Author manuscript; available in PMC: 2015 Jan 1.

Published in final edited form as: Am Heart J. 2013 Oct 22;167(1):10.1016/j.ahj.2013.10.009. doi: 10.1016/j.ahj.2013.10.009

Table III.

Effect of SCN5A-1103Y allele on ECG intervals

Interval	SCN5A-1103Y copy number						Effect^*
	0 = non-carriers		1 = heterozygous		2 = homozygous		Effect^*
	N	Adjusted^† mean (SE)	N	Adjusted^† mean (SE)	N	Adjusted^† mean (SE)	β^‡ (SE)	P
QT, milliseconds	3449	413.4 (0.35)	584	416.0 (0.84)	29	419.0 (3.77)	2.7 (0.83)	< .001
QTc, milliseconds	3449	425.0 (0.40)	584	428.3 (0.98)	29	432 (4.40)	3.3 (0.97)	< .001
JT, milliseconds	3449	320.5 (0.36)	584	323.9 (0.87)	29	327.0 (3.89)	3.4 (0.86)	< .001
JTc, milliseconds	3449	332.1 (0.41)	584	336.2 (1.01)	29	340.4 (4.5)	4.1 (0.99)	< .001
QRS, milliseconds	3568	93.1 (0.19)	614	91.6 (0.46)	30	90.8 (2.06)	−1.5 (0.45)	.001

Analyses were performed utilizing multivariable linear mixed models adjusting for covariates and accounting for familial correlation. Additive genetic models were used for these analyses.

^†

Adjusting for age, sex, R-R, and QRS for QT interval; for age, sex, and R-R for JT and QRS intervals; and for age and sex for QTc interval.

^‡

Model-estimated change per each additional copy of the SCN5A-1103Y allele.