FIGURE 4.
DMOG protection is abolished in A2BAR−/− mice. A2BAR−/− mice or littermate controls were pretreated with DMOG (5 mg i.p., 4 h prior to ischemia) or vehicle, followed by 15 min of ischemia and 3 h of reperfusion. Injury was measured for AST (A), IL-6 (B), TNF (C), and MPO (D). Results are expressed as the mean ± SEM of four to eight mice per group. E, H&E staining of jejunum sections (original magnification ×200). F, Quantification of ischemic injury. Results are expressed as median ± range (n = 3 mice/group).