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Inhibition of HIF with 17-DMAG increased injury in WT mice. WT mice were pretreated with 17-DMAG (1 mg i.p., 4 h prior to ischemia) or vehicle, followed by 15 min of ischemia and 3 h of reperfusion. Injury was measured for AST (A), IL-6 (B), TNF (C), and MPO (D). Results are expressed as the mean ± SEM of four mice/group.
