Table 2.

Proteins involved in miRNA biogenesis.

Gene	Description	Location	Function	Domains	Reference
Dicer	Dicer 1, ribonuclease type II	14q31	miRNA processing	Type 111 restriction enzyme, RNase3, DEAH, helicase, dsRBD, PAZ	[14]
AGO3	Argonaute 3	1p34-p34	Short-interfering-RNA-mediated gene silencing	PAZ, PIWI, DUF1785, DUF2344, DUF2678	[15]
Gemin3	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	1p13.2	RNA helicase	DEAD, Type 111 restriction enzyme, helicase C	[16]
Drosha	Drosha, ribonuclease type II	5p14-p13	Pri-miRNA processing	RNase3 domain, Double-stranded RNA binding motif	[17]
Exportin-5	Karyopherin family	6p21.1	Transport of small RNAs	Importin-beta N-terminal domain, exportin 1-like protein	[18]
FMRP	Fragile X mental retardation 1	Xq27.3	mRNA trafficking	KH domain	[19]
ADAR	Adenosine deaminase, RNA-specific	1q21.3	RNA and miRNA editing	z-Alpha, Dsrm, Editase	[20]
TRBP	TAR (HIV-1) RNA binding protein	12q12, q-13	Dicer stabilization	DZF, dsRBD	[21]
Importin-8	GTPase Ran mediate nuclear import	12p11.21	Nuclear localization of Argonaute proteins	Cse1	[22]
ELAV1	(Embryonic lethal, abnormal vision, Drosophila-like 1)	19p13.2	Repression of target sites	RBD	[23]
Dnd1	Dead end homolog 1	5q31.3	Inhibiting miRNA-mediated repression	PMP-22	[24]