Table 4.
miRNA involved in megakaryopoiesis.
| miRNA | Function | Putative targets | Reference |
|---|---|---|---|
| miR-34a | MK differentiation of K562 cells, targets cMyb, CDKs, and MEK1 | HMGN4, CCDC52, KLRK1, RGS17, NFATCG | [42, 43] |
|
| |||
| miR-155 | Downregulated in megakaryopoiesis, targets Meis-1 and Ets-1 | MMP16, SLC11A2, C2orf18 | [44] |
|
| |||
| miR-146a, miR-145 | Involved in megakaryopoiesis by activating innate immunity and mediates 5q syndrome phenotype | SOX11, SP1 | [45] |
|
| |||
| miR-146a | Increased in MK development and targets CXCR4 | CREBL2, NOTCH2, TRAK2, TBX18, RIN2, RAD23B, SLC1A2 | [46, 47] |
|
| |||
| miR-150 | Favours megakaryocyte lineage differentiation; it targets cMyb, induced by TPO | SLC24A4 | [47, 48] |
|
| |||
| miR-28 | It targets TPO receptor and prevents MK differentiation from CD34+ cells | [49] | |
|
| |||
| miR-27a | miR-27a targets and decrease RUNX1 levels | TRIM9, CYB5B, EGR2, BASP1 | [50] |
|
| |||
| miR-181a | miR-181a inhibit Ca2+ induced differentiation of MKs | [51] | |
|
| |||
| miR-125b-2 | Induces proliferation and differentiation of MKs | RAD98, ZNF100, PDS5B, SHE, CDR2 | [52] |
|
| |||
| miR-181 | Mediates MK differentiation by disrupting LIN28/let-7 axis | FOXP1, CCN8, HOXA1 | [53] |