Table 5.
miRNAs involved in erythropoiesis.
| MiRNA | Function | Putative targets | Reference |
|---|---|---|---|
| miR-144, miR-451 | Erythroid homeostasis, deficiency leads to splenomegaly, mild anaemia, and erythroid hyperplasia, controlled by GATA1 | TSPAN12, HMGCR, FBN2, MAP3K8, CXCL16, EREG, ATF2, CDKN2B | [54, 55] |
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| |||
| miR-451 | Erythroid differentiation defect and reduction in haematocrit in miRNA-451−/− mice | CDKN2B, CXCL16, EREG, ATF2 | [56] |
|
| |||
| miR-223 | Reduces the commitment of erythroid progenitors | LIN54, FOXO1, USP42, ALCAM, BCLAF1, SLC11A2 | [57, 58] |
|
| |||
| miR-15b, mi16, miR-22 | Positive correlation with erythroid markers CD36, CD235a, and CD71 | PRDM4, KIF1B, LAMP3, SWAP70, LIN7C, AKT3, LAMC1 | [59, 60] |
|
| |||
| miR-28 | Negatively correlate with CD71 | [59, 60] | |
|
| |||
| miR-320 | Favours CD71 transcriptional activities | [60] | |
|
| |||
| miR-221, miR-222 | Inhibit normal erythropoiesis | TAF9B, MYLIP, RAB18, CYP7A1, KIF16B, MAT2A, NXN | [61] |
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| |||
| miR-24 | Targets ALK4 | TRIB3, CBX5, KCNJ2, DGA52 | [62] |
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| |||
| miR-15a | Transition from BFU-E to CFU-E stage | GFAP, SLC9A8, ZNRF2, FAM81A | [63] |