Table 7.
miRNAs involved in CML.
| miRNA | Function | Putative targets | Reference |
|---|---|---|---|
| miR-17-92 | Down-regulated in imatinib treated CML cells | IRF9, RAB10, TXNIP, TET2 | [72] |
|
| |||
| miR-21 | Antisense inhibition leads to inhibition of migration and cell growth and induces apoptosis | TXPAN2, LUM, SUZ12, MSH2, PDZD2 | [73] |
|
| |||
| miR-203 | Methylated in AML, CML, ALL, CLL. Inhibit the expression of BCR-ABL | RTKN2, AAK1, MYST4 CD109, IL21, PLD2 | [74] |
|
| |||
| miR-451 | Associated with Bcr-Abl | TSC1, ACADSB, GRSF1, MAML1, GDI1, NAMPT | [75] |
|
| |||
| miR-29b | Inhibits ABL1 and BCR/ABL1 there by inhibiting cell growth and colony formation | HAS3, SNX24, CD93, SCML2, COL7A1, ZNF396, HMGCR, ICOS | [76] |
|
| |||
| miR-138 | Represses BCR/ABL1 and CCND3, increases by GATA1 | KLF12, H3F3B, MYO5C, NXN, NEBL, PDPN, STK38 | [77] |
|
| |||
| miR-212 | Increases the ABCG2 expression | APAF1, EP300, EDNRA, CFL2, NOS1, SOX4, SOX11 | [78] |