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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2013 Oct 3;273(2):10.1016/j.taap.2013.09.021. doi: 10.1016/j.taap.2013.09.021

Figure 2.

Figure 2

Effect of EGCG on β-catenin and its signaling proteins in human skin cancer cells. Cells were treated with various concentrations of EGCG for 48 h and cell lysates were used to detect the levels of proteins related with β-catenin signaling using western blot analysis. (A) Effect of EGCG on the nuclear accumulation of β-catenin and phosphorylation of β-catenin at critical residues and on the expression levels of regulatory kinases (GSK-3β, CK1α). (B) Effect of EGCG on COX-2 expression, and MMP-2 and MMP-9 proteins, which are downstream targets of β-catenin, in human skin cancer cells. β-actin served as the loading control.