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. 2013 Dec;19(12):1755–1766. doi: 10.1261/rna.040204.113

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© 2013 Rage et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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FIGURE 7. — Localization of Anxa2 and Cox4i2 mRNAs in axons of differentiated shSMN-NSC-34 cells is not affected at the same level upon SMN deficiency. (A) Spots corresponding to the indicated mRNAs (red) and colocalizing with the endogenous SMN protein (green spots) in axons of noninduced (NI) or induced (I) shSMN-NSC-34 cells are shown (merge). Imaris-generated images (red filter) show the amounts of RNA spots localized in axons before and following SMN depletion. Scale bar, 10 μm. (B) Histograms showing the percentage ± SEM of mRNA granules colocalizing with SMN spots (black) and of SMN spots colocalizing with mRNA granules (white). (*) P-value <0.05. (C) Histograms showing the average number ± SEM of SMN and RNA spots in axons of noninduced (NI) or induced (I) shSMN-NSC-34 cells. (*) P-value <0.05; (**) P-value <0.01.