Table II.
Fold expression changes of genes important to innate immunity as well as antigen presentation.
| YNG 2hr | Aged 2hr | YNG D1 | Aged D1 | Symbol | Name |
|---|---|---|---|---|---|
| Chemotaxis | |||||
| 5 | 2.9 | 9 | 2.7 | Ccl2 | chemokine ligand 2 |
| 3.5 | 2.9 | 7.3 | 3.9 | Ccr2 | chemokine receptor 2 |
| 1.4 | 1.8 | 3.3 | 1.4 | Ccr2 | chemokine receptor 2 |
| 3.8 | 2.5 | 11.6 | 4.6 | Ccr2 | chemokine receptor 2 |
| 2.4 | 1.8 | 1.7 | 1.2 | Ccr2 | chemokine receptor 2 |
| 59.9 | 7.9 | 12.9 | 3.3 | Cxcl1 | chemokine ligand 1 |
| 117 | 65.3 | 122.3 | 48.5 | Cxcl2 | chemokine ligand 2 |
| 262.9 | 93.1 | 104.5 | 31.2 | Cxcl3 | chemokine ligand 3 |
| Antimicrobial Peptides/Proteins | |||||
| 25.9 | 7.7 | 38.1 | 29.4 | Lcn2 | lipocalin 2 |
| 69 | 6.6 | 180 | 148.5 | Ltf | lactotransferrin |
| 3 | 1.3 | 5 | 2.7 | Ncf1 | neutrophil cytosolic factor 1 |
| 2 | −1.1 | 4 | 2.8 | Ncf1 | neutrophil cytosolic factor 1 |
| 3.5 | 1.4 | 7.4 | 3.9 | Ncf1 | neutrophil cytosolic factor 1 |
| 57.8 | 19.1 | 100.3 | 112 | Ngp | neutrophilic granule protein |
| 10.8 | 1.9 | 12.4 | 2.8 | Sod2 | superoxide dismutase 2, mitochondrial |
| 7.9 | 1.6 | 10.7 | 2.5 | Sod2 | superoxide dismutase 2, mitochondrial |
| 1.3 | 1.4 | 1 | −1.3 | Sod2 | superoxide dismutase 2, mitochondrial |
| 6.3 | 1.8 | 9.7 | 2.2 | Sod2 | superoxide dismutase 2, mitochondrial |
| PAMP Detection | |||||
| 26.5 | 6.2 | 19.1 | 10.6 | Cd14 | CD14 antigen |
| 14.2 | 6 | 5 | 4.2 | Tlr2 | toll-like receptor 2 |
| 2.7 | 3.7 | 5.5 | 2.8 | Tlr4 | toll-like receptor 4 |
| 1.7 | 2 | 4.1 | 3.2 | Tlr4 | toll-like receptor 4 |
| 2.8 | 3.6 | 5.5 | 2.9 | Tlr4 | toll-like receptor 4 |
| Other | |||||
| 3.1 | 1.4 | 17.4 | 5.3 | Cd38 | CD38 antigen |
| 1.7 | 1.4 | 2.8 | 2.6 | Ifngr1 | interferon γ receptor 1 |
| 28.4 | 10.5 | 30.7 | 25 | Mmp8 | matrix metallopeptidase 8 |
| 9.4 | 9 | 6.8 | 4.3 | Socs3 | suppressor of cytokine signaling 3 |
| 8.4 | 7.8 | 5.4 | 3.1 | Socs3 | suppressor of cytokine signaling 3 |
| 3.0 | 1.4 | 2.7 | 1.9 | Icam1 | intercellular adhesion molecule 1 |
| −2.1 | −3.4 | −1.4 | −2.3 | Icam2 | intercellular adhesion molecule 2 |
Select genes were identified from probe sets that were most upregulated in young/old mice after CLP. Almost every gene was more upregulated (fold change versus control) in the young mice at the early times points of 2 hours and 1 day (identified by bold and italics) as compared to the old mice. (YNG = young, D1 = day 1)