(a) GGT, γ-glutamyltranspeptidase, (b) AP, alkaline phosphatase, (c) CysC, cystatin C, (d) NGAL, neutrophil-gelatinase-associated lipocalin, (e) IL-18, interleukin-18, and (f) KIM-1, kidney injury molecule-1. All patients are included. AKI is AKI on entry or AKIN48 (AKI at any time within 48 h of entry to the ICU). Values shown are mean±s.e.m. There are approximately 50 measures at each time point for the AKI group. AKI, acute kidney injury; ICU, intensive care unit.