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. Author manuscript; available in PMC: 2014 Jan 8.
Published in final edited form as: Kidney Int. 2011 Feb 9;79(10):10.1038/ki.2010.555. doi: 10.1038/ki.2010.555

Table 5.

AUCs for AKI stratified according to time after insult

Time from insult <6h (n=178 [37]) 6 to <12h (n=94 [20]) 12 to <36h (n=115 [48]) ≥36h (n=107 [39])
Diagnosis of AKI (AKI on entry)a
  GGT/uCr 0.70 (0.60–0.80) 0.67 (0.52–0.81) 0.61 (0.50–0.71) 0.52 (0.40–0.63)
  AP/uCr 0.60 (0.49–0.71)b 0.49 (0.34–0.63)c 0.41 (0.30–0.51)d 0.39 (0.29–0.50)e
  CysC/uCr 0.67 (0.57–0.78) 0.75 (0.62–0.88) 0.68 (0.57–0.78) 0.52 (0.41–0.64)
  NGAL/uCr 0.66 (0.55–0.77) 0.65 (0.50–0.80) 0.71 (0.61–0.82)f 0.60 (0.48–0.72)
  IL-18/uCr 0.62 (0.52–0.73) 0.67 (0.53–0.81) 0.64 (0.53–0.74) 0.51 (0.39–0.62)
  KIM-1/uCr 0.62 (0.52–0.73) 0.66 (0.52–0.81) 0.67 (0.56–0.77) 0.61 (0.49–0.72)
Prediction of AKI (AKIN48)g <6h (n=141 [32]) 6 to <12h (n=74 [15]) 12 to <36h (n=67 [11]) ≥36h (n=68 [18])
GGT/uCr 0.50 (0.39–0.62) 0.71 (0.55–0.87)h 0.58 (0.39–0.77) 0.47 (0.31–0.62)
AP/uCr 0.59 (0.48–0.71) 0.63 (0.46–0.79) 0.42 (0.25–0.60) 0.47 (0.31–0.62)
CysC/uCr 0.48 (0.37–0.59) 0.61 (0.45–0.78) 0.48 (0.29–0.67) 0.73 (0.59–0.88)i
NGAL/uCr 0.53 (0.41–0.65) 0.49 (0.31–0.67) 0.55 (0.35–0.75) 0.60 (0.44–0.77)j
IL-18/uCr 0.38 (0.28–0.49)k 0.60 (0.43–0.77) 0.47 (0.28–0.65) 0.75 (0.60–0.89)l
KIM-1/uCr 0.54 (0.43–0.66) 0.57 (0.40–0.74) 0.47 (0.29–0.66) 0.48 (0.32–0.64)

Abbreviations: AKI, acute kidney injury; AKIN48, AKI within 48 h; AP, alkaline phosphatase; AUC, area under the receiver operator characteristic curve; CysC, cystatin C;GGT, γ-glutamyltranspeptidase; ICU, intensive care unit; IL-18, interleukin-18; KIM-1, kidney injury molecule-1; NGAL, neutrophil-gelatinase-associated lipocalin; uCr, urinary creatinine.

The number in square brackets is the number of patients with AKI.

a

AKI on entry: cohort: all patients on entry to the ICU (n=528).

b

<6 h: significantly lower than the AUC for GGT/uCr.

c

6 to <12 h: significantly lower than the AUCs for GGT/uCr, CysC/uCr, and KIM-1/uCr.

d

12 to <36 h: significantly lower than the AUCs for all other biomarkers.

e

≥36 h: significantly lower than the AUCs for GGT/uCr, NGAL/uCr, and KIM-1/uCr.

f

≥36 h: significantly higher than the AUCs for GGT/uCr and AP/uCr.

g

AKIN48: all patients on entry to the ICU without AKI on entry (n=381).

h

6 to <12 h: significantly higher than the AUC for NGAL/uCr.

i

≥36 h: significantly higher than the AUCs for all other biomarkers, except IL-18/uCr.

j

≥36 h: significantly higher than the AUCs for all other biomarkers, except CysC/uCr.

k

<6 h: significantly lower than the AUCs for all other biomarkers, except CysC/uCr.

l

≥36 h: significantly higher than the AUCs for GGT/uCr.