Table 6.
AUCs for AKI stratified according to eGFR
| eGFR | <60ml/min (n=96 [27]) |
60 to <90ml/min (n=172 [56]) |
90 to <120ml/min (n=162 [34]) |
≥120ml/min (n=96 [30]) |
|---|---|---|---|---|
| Diagnosis of AKI (AKI on entry)a | ||||
| GGT/uCr | 0.46 (0.33–0.59) | 0.60 (0.50–0.69) | 0.66 (0.55–0.76) | 0.62 (0.49–0.74) |
| AP/uCr | 0.37 (0.25–0.49) | 0.46 (0.37–0.55)b | 0.45 (0.35–0.56)b | 0.51 (0.38–0.63)c |
| CysC/uCr | 0.72 (0.60–0.84)d | 0.60 (0.51–0.70) | 0.75 (0.65–0.85)e | 0.66 (0.54–0.79) |
| NGAL/uCr | 0.64 (0.50–0.78)d | 0.64 (0.54–0.73) | 0.70 (0.59–0.81) | 0.69 (0.56–0.81)f |
| IL-18/uCr | 0.65 (0.52–0.77)d | 0.60 (0.51–0.69) | 0.67 (0.56–0.78) | 0.56 (0.43–0.68) |
| KIM-1/uCr | 0.70 (0.58–0.82)d | 0.68 (0.59–0.77) | 0.63 (0.52–0.74) | 0.61 (0.49–0.74) |
| Prediction of AKI (AKIN48)g | <60ml/min (n=69 [20]) | 60 to <90ml/min (n=116 [25]) | 90 to <120ml/min (n=128 [26]) | ≥120ml/min (n=66 [11]) |
| GGT/uCr | 0.79 (0.66–0.92) | 0.48 (0.35–0.60) | 0.50 (0.37–0.62) | 0.56 (0.36–0.75)h |
| AP/uCr | 0.71 (0.56–0.85) | 0.48 (0.35–0.60) | 0.54 (0.41–0.66) | 0.55 (0.36–0.74) |
| CysC/uCr | 0.64 (0.49–0.79) | 0.54 (0.41–0.67) | 0.58 (0.45–0.71) | 0.35 (0.18–0.51) |
| NGAL/uCr | 0.71 (0.56–0.87) | 0.53 (0.39–0.67) | 0.53 (0.41–0.66) | 0.44 (0.25–0.63) |
| IL-18/uCr | 0.65 (0.50–0.80) | 0.48 (0.35–0.60) | 0.57 (0.45–0.70) | 0.49 (0.30–0.67) |
| KIM-1/uCr | 0.66 (0.52–0.81) | 0.44 (0.32–0.56) | 0.65 (0.52–0.77) | 0.37 (0.20–0.54) |
Abbreviations: AKI, acute kidney injury; AKIN48, AKI within 48 h; AP, alkaline phosphatase; AUC, area under the receiver operator characteristic curve; CysC, cystatin C; eGFR, estimated glomerular filtration rate; GGT, γ-glutamyltranspeptidase; ICU, intensive care unit; IL-18, interleukin-18; KIM-1, kidney injury molecule-1; NGAL, neutrophil-gelatinase-associated lipocalin; uCr, urinary creatinine.
The number in square brackets is the number of patients with AKI.
AKI on entry: cohort: all patients on entry to the ICU (n=528).
60 to <90 ml/min and 90 to <120 ml/min: significantly lower than the AUCs for all other biomarkers.
≥120 ml/min: significantly lower than the AUCs for GGT/uCr, CysC/uCr, and NGAL/uCr.
<60 ml/min: significantly higher than the AUCs for GGT/uCr and AP/uCr.
90 to <120 ml/min: significantly higher than the AUCs for AP/uCr and KIM-1/uCr.
≥120 ml/min: significantly higher than the AUCs for AP/uCr and IL-18/uCr.
AKIN48: cohort: all patients on entry to the ICU without AKI on entry (n=381).
≥120 ml/min: significantly higher than the AUCs for CysC/uCr and KIM-1/uCr.