AUC for diagnosis of AKI according to time after insult and eGFR

eGFR (ml/min)	Time from insult	<6h n=24 [3]	6 to <12h n=40 [4]	12 to <36h n=12 [8]	≥36h n=20 [12]
<60	GGT/uCr	0.41 (0.08–0.75)	0.26 (0.04–0.49)	0.91 (0.73–1)	0.48 (0.21–0.74)
	AP/uCr	0.17 (0–0.38)	0.19 (0.01–0.37)	0.62 (0.29–0.96)	0.40 (0.13–0.66)
	CysC/uCr	0.69 (0.34–1)	0.65 (0.35–0.96)	0.88 (0.67–1)	0.44 (0.17–0.70)
	NGAL/uCr	0.45 (0.10–0.80)	0.39 (0.07–0.7)	0.85 (0.58–1)	0.58 (0.32–0.84)
	IL-18/uCr	0.62 (0.26–0.98)	0.61 (0.30–0.92)	0.94 (0.80–1)	0.41 (0.14–0.67)
	KIM-1/uCr	0.73 (0.39–1)	0.43 (0.14–0.72)	0.66 (0.33–0.98)	0.65 (0.40–0.89)
		n=64 [14]	n=27 [9]	n=43 [16]	n=38 [17]
60–<90	GGT/uCr	0.70 (0.53–0.86)	0.69 (0.46–0.91)	0.67 (0.50–0.84)	0.48 (0.30–0.67)
	AP/uCr	0.65 (0.47–0.82)	0.55 (0.31–0.79)	0.38 (0.21–0.55)	0.41 (0.23–0.59)
	CysC/uCr	0.63 (0.46–0.81)	0.65 (0.42–0.88)	0.59 (0.41–0.77)	0.40 (0.22–0.58)
	NGAL/uCr	0.58 (0.40–0.76)	0.60 (0.35–0.85)	0.72 (0.54–0.89)	0.52 (0.33–0.72)
	IL-18/uCr	0.61 (0.44–0.79)	0.73 (0.52–0.95)	0.58 (0.40–0.76)	0.43 (0.24–0.61)
	KIM-1/uCr	0.75 (0.59–0.91)	0.66 (0.43–0.89)	0.72 (0.56–0.89)	0.44 (0.26–0.63)
		n=56 [10]	n=35 [5]	n=35 [14]	n=32 [5]
90–<120	GGT/uCr	0.87 (0.73–1)	0.85 (0.64–1)	0.47 (0.28–0.66)	0.70 (0.42–0.97)
	AP/uCr	0.64 (0.44–0.84)	0.60 (0.32–0.88)	0.38 (0.20–0.56)	0.29 (0.07–0.51)
	CysC/uCr	0.83 (0.67–0.99)	0.89 (0.70–1)	0.74 (0.57–0.91)	0.64 (0.36–0.93)
	NGAL/uCr	0.82 (0.65–1)	0.64 (0.33–0.95)	0.73 (0.55–0.91)	0.52 (0.23–0.80)
	IL-18/uCr	0.71 (0.52–0.91)	0.78 (0.52–1)	0.66 (0.47–0.84)	0.52 (0.24–0.80)
	KIM-1/uCr	0.53 (0.33–0.74)	0.85 (0.63–1)	0.59 (0.40–0.78)	0.73 (0.47–1)
		n=33 [10]	n=21 [3]	n=22 [11]	n=20 [6]
≥120	GGT/uCr	0.67 (0.45–0.88)	0.78 (0.45–1)	0.54 (0.29–0.78)	0.61 (0.32–0.89)
	AP/uCr	0.65 (0.43–0.86)	0.63 (0.26–1)	0.32 (0.10–0.55)	0.40 (0.13–0.67)
	CysC/uCr	0.60 (0.38–0.81)	0.75 (0.40–1)	0.64 (0.40–0.87)	0.76 (0.50–1)
	NGAL/uCr	0.66 (0.43–0.88)	0.72 (0.37–1)	0.68 (0.45–0.91)	0.63 (0.33–0.94)
	IL-18/uCr	0.54 (0.32–0.76)	0.54 (0.17–0.9)	0.45 (0.21–0.7)	0.64 (0.36–0.92)
	KIM-1/uCr	0.46 (0.24–0.67)	0.61 (0.24–0.98)	0.64 (0.40–0.87)	0.62 (0.34–0.90)

Abbreviations: AKI, acute kidney injury; AP, alkaline phosphatase; AUC, area under the receiver operator characteristic curve; CysC, cystatin C; eGFR, estimated glomerular filtration rate; GGT, γ-glutamyltranspeptidase; IL-18, interleukin-18; KIM-1, kidney injury molecule-1; NGAL, neutrophil-gelatinase-associated lipocalin; uCr, urinary creatinine.

n=total number in category. Square brackets show number of patients with AKI.