eGFR (ml/min) | Time from insult | <6h n=24 [3] |
6 to <12h n=40 [4] |
12 to <36h n=12 [8] |
≥36h n=20 [12] |
---|---|---|---|---|---|
<60 | GGT/uCr | 0.41 (0.08–0.75) | 0.26 (0.04–0.49) | 0.91 (0.73–1) | 0.48 (0.21–0.74) |
AP/uCr | 0.17 (0–0.38) | 0.19 (0.01–0.37) | 0.62 (0.29–0.96) | 0.40 (0.13–0.66) | |
CysC/uCr | 0.69 (0.34–1) | 0.65 (0.35–0.96) | 0.88 (0.67–1) | 0.44 (0.17–0.70) | |
NGAL/uCr | 0.45 (0.10–0.80) | 0.39 (0.07–0.7) | 0.85 (0.58–1) | 0.58 (0.32–0.84) | |
IL-18/uCr | 0.62 (0.26–0.98) | 0.61 (0.30–0.92) | 0.94 (0.80–1) | 0.41 (0.14–0.67) | |
KIM-1/uCr | 0.73 (0.39–1) | 0.43 (0.14–0.72) | 0.66 (0.33–0.98) | 0.65 (0.40–0.89) | |
n=64 [14] | n=27 [9] | n=43 [16] | n=38 [17] | ||
60–<90 | GGT/uCr | 0.70 (0.53–0.86) | 0.69 (0.46–0.91) | 0.67 (0.50–0.84) | 0.48 (0.30–0.67) |
AP/uCr | 0.65 (0.47–0.82) | 0.55 (0.31–0.79) | 0.38 (0.21–0.55) | 0.41 (0.23–0.59) | |
CysC/uCr | 0.63 (0.46–0.81) | 0.65 (0.42–0.88) | 0.59 (0.41–0.77) | 0.40 (0.22–0.58) | |
NGAL/uCr | 0.58 (0.40–0.76) | 0.60 (0.35–0.85) | 0.72 (0.54–0.89) | 0.52 (0.33–0.72) | |
IL-18/uCr | 0.61 (0.44–0.79) | 0.73 (0.52–0.95) | 0.58 (0.40–0.76) | 0.43 (0.24–0.61) | |
KIM-1/uCr | 0.75 (0.59–0.91) | 0.66 (0.43–0.89) | 0.72 (0.56–0.89) | 0.44 (0.26–0.63) | |
n=56 [10] | n=35 [5] | n=35 [14] | n=32 [5] | ||
90–<120 | GGT/uCr | 0.87 (0.73–1) | 0.85 (0.64–1) | 0.47 (0.28–0.66) | 0.70 (0.42–0.97) |
AP/uCr | 0.64 (0.44–0.84) | 0.60 (0.32–0.88) | 0.38 (0.20–0.56) | 0.29 (0.07–0.51) | |
CysC/uCr | 0.83 (0.67–0.99) | 0.89 (0.70–1) | 0.74 (0.57–0.91) | 0.64 (0.36–0.93) | |
NGAL/uCr | 0.82 (0.65–1) | 0.64 (0.33–0.95) | 0.73 (0.55–0.91) | 0.52 (0.23–0.80) | |
IL-18/uCr | 0.71 (0.52–0.91) | 0.78 (0.52–1) | 0.66 (0.47–0.84) | 0.52 (0.24–0.80) | |
KIM-1/uCr | 0.53 (0.33–0.74) | 0.85 (0.63–1) | 0.59 (0.40–0.78) | 0.73 (0.47–1) | |
n=33 [10] | n=21 [3] | n=22 [11] | n=20 [6] | ||
≥120 | GGT/uCr | 0.67 (0.45–0.88) | 0.78 (0.45–1) | 0.54 (0.29–0.78) | 0.61 (0.32–0.89) |
AP/uCr | 0.65 (0.43–0.86) | 0.63 (0.26–1) | 0.32 (0.10–0.55) | 0.40 (0.13–0.67) | |
CysC/uCr | 0.60 (0.38–0.81) | 0.75 (0.40–1) | 0.64 (0.40–0.87) | 0.76 (0.50–1) | |
NGAL/uCr | 0.66 (0.43–0.88) | 0.72 (0.37–1) | 0.68 (0.45–0.91) | 0.63 (0.33–0.94) | |
IL-18/uCr | 0.54 (0.32–0.76) | 0.54 (0.17–0.9) | 0.45 (0.21–0.7) | 0.64 (0.36–0.92) | |
KIM-1/uCr | 0.46 (0.24–0.67) | 0.61 (0.24–0.98) | 0.64 (0.40–0.87) | 0.62 (0.34–0.90) |
Abbreviations: AKI, acute kidney injury; AP, alkaline phosphatase; AUC, area under the receiver operator characteristic curve; CysC, cystatin C; eGFR, estimated glomerular filtration rate; GGT, γ-glutamyltranspeptidase; IL-18, interleukin-18; KIM-1, kidney injury molecule-1; NGAL, neutrophil-gelatinase-associated lipocalin; uCr, urinary creatinine.
n=total number in category. Square brackets show number of patients with AKI.