AUC for prediction of AKI in patients without AKI on entry according to time after insult and eGFR

eGFR (ml/min)	Time from insult	<6h n=21 [5]	6 to <12h n=36 [10]	12 to <36 h n=4 [2]	≥36h n=8 [3]
<60	GGT/uCr	0.96 (0.84–1)	0.81 (0.64–0.99)	0.50 (0–1)	0.93 (0.71–1)
	AP/uCr	0.99 (0.92–1)	0.71 (0.51–0.91)	0.50 (0–1)	0.67 (0.25–1)
	CysC/uCr	0.76 (0.49–1)	0.59 (0.38–0.81)	0.38 (0–0.99)	1 (1–1)
	NGAL/uCr	0.76 (0.49–1)	0.65 (0.4–0.89)	0.50 (0–1)	0.87 (0.56–1)
	IL-18/uCr	0.57 (0.27–0.87)	0.75 (0.56–0.94)	0.50 (0–1)	0.67 (0.25–1)
	KIM-1/uCr	0.81 (0.57–1.1)	0.64 (0.43–0.85)	0.50 (0–1)	0.33 (0–0.73)
		n=50 [12]	n=18 [4]	n=27 [3]	n=21 [6]
60–<90	GGT/uCr	0.29 (0.13–0.44)	0.80 (0.52–1)	0.72 (0.38–1)	0.50 (0.22–0.78)
	AP/uCr	0.38 (0.21–0.56)	0.52 (0.19–0.85)	0.43 (0.09–0.77)	0.58 (0.3–0.86)
	CysC/uCr	0.41 (0.23–0.59)	0.61 (0.27–0.94)	0.54 (0.18–0.90)	0.89 (0.70–1)
	NGAL/uCr	0.43 (0.25–0.61)	0.46 (0.03–0.90)	0.70 (0.27–1.1)	0.64 (0.34–0.94)
	IL-18/uCr	0.31 (0.15–0.47)	0.64 (0.31–0.97)	0.25 (0–0.50)	0.86 (0.65–1)
	KIM-1/uCr	0.41 (0.23–0.59)	0.61 (0.27–0.94)	0.24 (0–0.48)	0.51 (0.23–0.79)
		n=46 [10]	n=30 [4]	n=25 [4]	n=27 [8]
90–<120	GGT/uCr	0.52 (0.31–0.73)	0.57 (0.25–0.88)	0.51 (0.20–0.83)	0.39 (0.17–0.62)
	AP/uCr	0.61 (0.40–0.82)	0.64 (0.33–0.96)	0.42 (0.12–0.71)	0.46 (0.22–0.7)
	CysC/uCr	0.47 (0.27–0.67)	0.55 (0.23–0.86)	0.52 (0.16–0.87)	0.68 (0.44–0.91)
	NGAL/uCr	0.61 (0.40–0.82)	0.47 (0.17–0.77)	0.50 (0.18–0.82)	0.56 (0.31–0.8)
	IL-18/uCr	0.35 (0.17–0.53)	0.56 (0.24–0.88)	0.67 (0.35–0.98)	0.84 (0.65–1)
	KIM-1/uCr	0.62 (0.41–0.82)	0.58 (0.26–0.90)	0.59 (0.27–0.91)	0.71 (0.48–0.94)
		n=23 [5]	n=18 [2]	n=11 [2]	n=14 [2]
≥120	GGT/uCr	0.54 (0.25–0.84)	0.47 (0.041–0.9)	0.61 (0.14–1)	0.58 (0.13–1)
	AP/uCr	0.72 (0.44–1)	0.44 (0.02–0.86)	0.39 (0–0.82)	0.42 (0–0.84)
	CysC/uCr	0.36 (0.09–0.62)	0.33 (0–0.71)	0.42 (0–0.86)	0.32 (0–0.7)
	NGAL/uCr	0.48 (0.19–0.77)	0.22 (0–0.51)	0.67 (0.21–1)	0.27 (0.19–0.74)
	IL-18/uCr	0.46 (0.17–0.74)	0.47 (0.04–0.9)	0.50 (0.04–0.96)	0.52 (0.07–0.97)
	KIM-1/uCr	0.46 (0.17–0.74)	0.41 (0–0.81)	0.39 (0.04–0.82)	0.083 (0–0.25)

Abbreviations: AKI, acute kidney injury; AP, alkaline phosphatase; AUC, area under the receiver operator characteristic curve; CysC, cystatin C; eGFR, estimated glomerular filtration rate; GGT, γ-glutamyltranspeptidase; IL-18, interleukin-18; KIM-1, kidney injury molecule-1; NGAL, neutrophil-gelatinase-associated lipocalin; uCr, urinary creatinine.

n=total number in category. Square brackets show number of patients with AKI.