Table 5.

Cox multivariate analysis for disease-specific survival in gastric cancer subgroups.

Subgroups	Prognostic factor	Univariate	Multivariate	Hazard Ratio (95.0% CI)
Undifferentiated cancer	TNM stage (stage I)	<0.001	<0.001
	stage II		0.093	3.952 (0.797-19.602)
	stage III		<0.001	22.756 (5.045-102.636)
	stage IV		<0.001	66.992 (13.865-323.682)
	Lymphatic invasion	<0.001	0.695	1.138 (0.596-2.176)
	Venous invasion	<0.001	0.551	1.168 (0.7-1.949)
	Perineural invasion	<0.001	0.450	0.799 (0.447-1.43)
	Protein expression (expression/loss)	0.002	0.020	1.927 (1.11-3.345)
AGC	N stage (N0)	<0.001	<0.001
	N1		0.120	2.273 (0.808-6.389)
	N2		<0.001	5.390 (2.156-13.474)
	N3		<0.001	11.861 (5.11-27.527)
	Differentiation	0.030	0.129	1.355 (0.915-2.005)
	Lymphatic invasion	<0.001	0.471	0.816 (0.469-1.419)
	Venous invasion	<0.001	0.014	1.617 (1.102-2.372)
	Perineural invasion	<0.001	0.330	1.242 (0.803-1.922)
	Protein expression (expression/loss)	0.004	0.019	1.625 (1.084-2.437)
N+ cancer	T stage (T1)	<0.001	<0.001
	T2		0.777	1.415 (0.128-15.624)
	T3		0.017	11.136 (1.539-80.597)
	T4		0.004	18.573 (2.569-134.283)
	Differentiation	0.034	0.151	1.342 (0.898-2.004)
	Lymphatic invasion	0.023	0.781	1.085 (0.609-1.934)
	Venous invasion	<0.001	0.006	1.714 (1.171-2.509)
	Perineural invasion	<0.001	0.469	0.833 (0.507-1.367)
	Protein expression (expression/loss)	0.012	0.023	1.602 (1.068-2.402)
Stage II /III	Age(≤70 vs. >70 yr)	0.019	0.050	1.646 (0.999-2.712)
	TNM stage (stage II vs. III)	<0.001	<0.001	6.416 (3.181-12.941)
	Venous invasion	<0.001	0.041	1.683 (1.021-2.773)
	Protein expression (expression/loss)	0.021	0.010	1.916 (1.166-3.149)

AGC indicates gastric cancer with ≥ T2 stage. N+ indicates gastric cancer with ≥ N1 stage.