Table 3. Detection of SFTSV RNA and virus-specific antibody in serum samples of 24 patients, Shandong Province, China, 2011*.
Patient no. or parameter |
Day of blood collection after disease onset |
Acute-phase serum samples, n = 24 |
|
Convalescent-phase serum samples, n = 21 | RT-PCR– or ELISA–confirmed SFTSV cases, n = 24 |
|
---|---|---|---|---|---|---|
RT-PCR, S RNA segment |
ELISA titer |
ELISA titer |
||||
1 | 5 | – | 2 | 0 | + | |
2 | 10 | + | 64 | ND | + | |
3 | 6 | – | 0 | 64 | + | |
4 | 4 | – | 0 | 0 | – | |
5 | 9 | – | 256 | ≥512 | + | |
6 | 7 | + | 0 | ≥512 | + | |
7 | 4 | +† | 0 | 128 | + | |
8 | 13 | – | 0 | 128 | + | |
9 | 5 | – | 0 | 0 | – | |
10 | 7 | +† | 0 | 256 | + | |
11 | 6 | – | 0 | 256 | + | |
12 | 6 | + | 64 | ≥512 | + | |
13 | 7 | +† | 0 | ≥512 | + | |
14 | 5 | – | 256 | ≥512 | + | |
15 | 4 | +† | 0 | ≥512 | + | |
16 | 10 | + | 0 | ND | + | |
17 | 6 | + | 32 | 128 | + | |
18 | 13 | – | 512 | NA | + | |
19 | 10 | – | 64 | 256 | + | |
20 | 10 | – | 256 | 256 | + | |
21 | 7 | + | 512 | 256 | + | |
22 | 6 | + | 32 | ≥512 | + | |
23 | 8 | + | 32 | 32 | + | |
24 |
6 |
– |
64 |
|
256 |
+ |
SFTSV positivity rate, % | NA | 50 | 54 | 86 | 92 | |
Sensitivity, % | NA | 55 | 59 | 95 | NA |
* SFTSV positivity rate was calculated by using patients given a clinical diagnosis (n = 24) as the denominator. Sensitivity was calculated by using laboratory-confirmed cases (n = 22) as the denominator. SFTSV, severe fever with thrombocytopenia syndrome virus; RT-PCR, reverse transcription PCR; S, small; –, negative; +, positive; ND, not determined; NA, not applicable. †Positive by RT-PCR for S and large segments.