Table 2. Description of scenarios for the economic evaluation of rotavirus vaccination, Kazakhstan.
Scenario | Vaccine parameters |
Children <5 y of age, calibration to 2009 sentinel data |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
Mean duration of protection, mo | Coverage | Efficacy against severe RVGE | Efficacy against mild RVGE | Deaths | Hospital admissions | Outpatient clinic visits* | Homecare episodes* | |||
Base case | 12 | 0.9 | 0.80 | 0.58 | 68 | 4,007 | Is-0.2Ih | Im | ||
Base case, low | 12 | 0.9 | 0.74 | 0.51 | 63 | 3,740 | 0.6 | 0.5Im | ||
Base case, high | 12 | 0.9 | 0.86 | 0.64 | 74 | 4,274 | 1.4 | 1.5Im | ||
Scenario A | 12 | 0.89 | 0.80 | 0.58 | 68 | 4,007 | Is-0.2Ih | Im | ||
Scenario A, low | 12 | 0.89 | 0.74 | 0.51 | 63 | 3,740 | 0.6 | 0.5Im | ||
Scenario A, high | 12 | 0.89 | 0.86 | 0.64 | 74 | 4,274 | 1.4( | 1.5Im | ||
Scenario B | 12 | 1.0 | 0.80 | 0.58 | 68 | 4,007 | Is-0.2Ih | Im | ||
Scenario B, low | 12 | 1.0 | 0.74 | 0.51 | 63 | 3,740 | 0.6 | 0.5Im | ||
Scenario B, high | 12 | 1.0 | 0.86 | 0.64 | 74 | 4,274 | 1.4 | 1.5Im | ||
Scenario C | 24 | 0.9 | 0.80 | 0.58 | 68 | 4,007 | Is-0.2Ih | Im | ||
Scenario C, low | 24 | 0.9 | 0.74 | 0.51 | 63 | 3,740 | 0.6 | 0.5Im | ||
Scenario C, high | 24 | 0.9 | 0.86 | 0.64 | 74 | 4,274 | 1.4 | 1.5Im |
*RVGE, rotavirus gastroenteritis; Is, modeled incidence of severe RVGE; Ih, modeled incidence of hospital admissions; Im, modeled incidence of mild RVGE. †The numbers of outpatient clinic and homecare visits were not calibrated.